Combined modality preoperative therapy in poor prognostic rectal adenocarcinoma

摘要: Between 1976 and 1986, 64 patients with rectal adenocarcinoma who were considered unresectable or had prognostic signs suggestive of high risk for local failure received preoperative adjuvant therapy. They treated pelvic irradiation (40 Gy) combined 5-fluorouracil (5-FU) mitomycin-C, followed by surgery. All definitive resections resulting in 12.5% operative specimens free tumor only 26.5% containing nodal metastases. The projected 5-year disease-free survival rate is 64% an actuarial 68%. No mortality severe morbidity has been observed. Combined modality therapy a safe effective regimen those tumors the category.