Genetic differences between B27 positive patients with ankylosing spondylitis and B27 positive healthy controls.

摘要: In a controlled study of the 499 available first degree relatives 79 consecutive HLA-B27 positive patients with ankylosing spondylitis and 69 healthy blood donors, 19 cases were found: 16 (15 B27 positive) among 282 spondylitis, 3 (1 positive, 1 negative, unknown) 217 donors (chi c2 = 5.11; P less than 0.025). However, if all possible spondylarthritis are included, 48 37 11 8.29; 0.01). Assuming that 50% individuals carry this antigen, 15 142 (10.6%) 2 108 (1.9%) subjects 5.91; 0.025) have spondylitis. The relative risk spondylarthropathy for compared is 5.6. evaluated in similar manner, analysis these data suggests genetic differences between diseased subjects.