Synthetic cathinones related fatalities: an update.

摘要: Objective Synthetic cathinones, more commonly known as "bath salts", are synthetic drugs chemically related to cathinone, a psychostimulant found in the khat plant. They first most consumed products among new psychoactive substances, which cause and hallucinogenic effects determining number of fatalities worldwide. In this paper, we have systematically reviewed cases cathinones-related analytically confirmed, occurred last few years. Materials methods Relevant scientific articles were identified Medline, Cochrane Central, Scopus, Web Science Institutional/government websites up November 2017 using following keywords: mephedrone, methylenedioxypyrovalerone, MDPV, methylone, ethylone, buthylone, fatal intoxication, death. Results total, 20 citations met criteria for inclusion, representing several with confirmed cathinones biological sample/s deceased. The death was attributed hyperthermia, hypertension, cardiac arrest general classic serotonin syndrome. Only rarely did concentration parent drug causing fatality overcome value 1 mg/L post-mortem fluids. Conclusions Abuse still represents serious public health issue. Systematic clinical studies on both animal human model lacking; therefore, only available data from users who experience possible hazardous consequences. Analytical methodologies identification compounds eventual metabolites ante-mortem need be developed validated. should shared through different communication platforms aim stopping threat users.