Functional connectivity of thalamus in children with primary nocturnal enuresis: results from a resting-state fMRI study.

摘要: Primary nocturnal enuresis (PNE) is characterized by a low cure rate and high reoccurrence rate, since its underlying mechanism remains unclear. Based on the recent studies that thalamus plays an important role in waking up sleeping person, here we further investigate functional connectivity (FC) information between other brain regions, order to make better understanding of PNE's pathogenesis. In this study, enrolled 30 children diagnosed with PNE typically developing are age sex matched, thalamus-based FC estimates were extracted at resting-state. Experiments showed for PNE, there four regions found reduced connection efficiency thalamus, cerebellum posterior lobe, frontal parietal lobe precentral gyrus. It can be concluded these relevant might induce arousal disorder, therefore lead PNE. This finding also provides new insight pathophysiology