Intrauterine Transplantation of Rat Basal Cell Carcinoma as a Model for Reconversion of Malignant to Benign Growth

摘要: Basal cell carcinomas resembling those of human skin were produced in rat by the local application 3-methylcholanthrene. Fragments transplanted into uterus estradiol-treated virgin females. Sizable tumors obtained 9 days to 3 weeks. Histological examination showed that increasing numbers small basaloid tumor cells change larger prickle benign appearance, which form keratinizing foci and cysts within growing nodules spread over surface uterine lumen glands, replacing columnar epithelium. Between 4 6 weeks after implantation, no nodular growth was found, progressively stretches covered with stratified epithelium, light microscopic standards resembled morphology behavior epidermis spreading from normal implants under similar conditions. The results lend support thesis epithelial basal are stimulated continuous neoplastic proliferation, prevented maturing stimuli specific stroma, will express their differentiation potential when exposed stroma. method used appears provide a model reconversion malignant be amenable further experimental analysis.