Mammary Gland Involution as an Immunotherapeutic Target for Postpartum Breast Cancer

摘要: Postpartum mammary gland involution has been identified as tumor-promotional and is proposed to contribute the increased rates of metastasis poor survival observed in postpartum breast cancer patients. In rodent models, involuting microenvironment sufficient induce enhanced tumor cell growth, local invasion, metastasis. shares many attributes with wound healing, including upregulation genes involved immune responsiveness infiltration tissue by cells. treatment non-steroidal anti-inflammatory drugs (NSAIDs) ameliorates effects involution, consistent milieu contributing promotion. Currently, immunotherapy being investigated a means purpose identifying ways enhance anti-tumor responses. Here we review evidence for uniquely defined ‘hot-spot’ pro-tumorigenic infiltration, propose that should be explored prevention cancers arise this environment.