Self-Control and External Control of Mechanical Ventilation Give Equal Air Hunger Relief

摘要: Elevated end-tidal partial pressure of CO2 (Pet ) causes air hunger; this sensation becomes intense with a relatively small rise in Pet if ventilation is held constant. Spontaneously breathing subjects increase response to CO2, thereby greatly diminishing hunger. In healthy and ventilator-dependent patients, experimenter-induced increases ventilator tidal volume (Vt) relieve hunger even kept elevated. We addressed two questions: (1) Can paralyzed, patients use the effectively control Vt using nonrespiratory motor pathways; (2) Do obtain more relief when their own ventilator? Four were trained mouth-operated switch. Subjects' ratings intensity elevated compared during three conditions: constant Vt; subject-controlled (3) experimenter-controlled Vt. When given control...