Novel β-TCP/PVA bilayered hydrogels with considerable physical and bio-functional properties for osteochondral repair
作者： Hang Yao , Junpei Kang , Weichang Li , Jian Liu , Renjian Xie
关键词:
摘要: Cartilage repairing grafts have been widely studied, and osteochondral replacement hydrogels proven to be an excellent method in research clinical fields. However, it has difficult simultaneously solve three main issues preparation: surface lubrication, overall mechanical support good simulations of cell regeneration. A novel integrated bilayered hydrogel was constructed by blending polyvinyl alcohol (PVA) β-tricalcium phosphate (β-TCP) this study. Separated nano-ball milling with ultrasound dispersion prepared β-TCP demonstrated suitable properties tiny particle size, high purity ideal distribution, improving the hydrogel, providing a cartilage-like lubrication effect biocompatibility, including cytocompatibility osteogenesis. The reinforcement molding technology enabled demonstrate component compatibility bonding between two layers, which promoted strengthening compression modulus tensile up times testing. were similar natural cartilage friction coefficient characterization. layers graft provided considerable bio-function co-culturing chondrocytes synovium mesenchymal stem cells: adherence achieved upper density layer better osteogenesis performance porous lower layer. design β-TCP/PVA is promising for use articular repair.
harvard.edu
sci-hub.se 参考文章(52)
Xavier Banquy, Dong Woog Lee, Saurabh Das, Jack Hogan, Jacob N. Israelachvili, Shear-induced aggregation of mammalian synovial fluid components under boundary lubrication conditions Advanced Functional Materials. ,vol. 24, pp. 3152- 3161 ,(2014) , 10.1002/ADFM.201302959
Ting Ting Lau, Chunming Wang, Dong-An Wang, Cell delivery with genipin crosslinked gelatin microspheres in hydrogel/microcarrier composite Composites Science and Technology. ,vol. 70, pp. 1909- 1914 ,(2010) , 10.1016/J.COMPSCITECH.2010.05.015
Avijit Guha, Suprabha Nayar, Low-Temperature Biomimetic Synthesis of β-Tricalcium Phosphate by Altering pH Synthesis and Reactivity in Inorganic Metal-organic and Nano-metal Chemistry. ,vol. 44, pp. 789- 792 ,(2014) , 10.1080/15533174.2011.652272
Jiabing Fan, Yihong Gong, Li Ren, Rohan R. Varshney, Daozhang Cai, Dong-An Wang, In vitro engineered cartilage using synovium-derived mesenchymal stem cells with injectable gellan hydrogels. Acta Biomaterialia. ,vol. 6, pp. 1178- 1185 ,(2010) , 10.1016/J.ACTBIO.2009.08.042
Kai Su, Ting Ting Lau, Wenyan Leong, Yihong Gong, Dong-An Wang, Creating a Living Hyaline Cartilage Graft Free from Non‐Cartilaginous Constituents: An Intermediate Role of a Biomaterial Scaffold Advanced Functional Materials. ,vol. 22, pp. 972- 978 ,(2012) , 10.1002/ADFM.201102884
Weeraphat Pon-On, Narattaphol Charoenphandhu, Jarinthorn Teerapornpuntakit, Jirawan Thongbunchoo, Nateetip Krishnamra, I-Ming Tang, Mechanical properties, biological activity and protein controlled release by poly(vinyl alcohol)–bioglass/chitosan–collagen composite scaffolds: A bone tissue engineering applications Materials Science and Engineering: C. ,vol. 38, pp. 63- 72 ,(2014) , 10.1016/J.MSEC.2014.01.040
Hongli Sun, Chengtie Wu, Kerong Dai, Jiang Chang, Tingting Tang, Proliferation and osteoblastic differentiation of human bone marrow-derived stromal cells on akermanite-bioactive ceramics. Biomaterials. ,vol. 27, pp. 5651- 5657 ,(2006) , 10.1016/J.BIOMATERIALS.2006.07.027
Jasmine Seror, Linyi Zhu, Ronit Goldberg, Anthony J. Day, Jacob Klein, Supramolecular synergy in the boundary lubrication of synovial joints Nature Communications. ,vol. 6, pp. 6497- 6497 ,(2015) , 10.1038/NCOMMS7497
E.B. Hunziker, T.M. Quinn, H.-J. Häuselmann, Quantitative structural organization of normal adult human articular cartilage. Osteoarthritis and Cartilage. ,vol. 10, pp. 564- 572 ,(2002) , 10.1053/JOCA.2002.0814
Kara L. Spiller, Suzanne A. Maher, Anthony M. Lowman, Hydrogels for the Repair of Articular Cartilage Defects Tissue Engineering Part B-reviews. ,vol. 17, pp. 281- 299 ,(2011) , 10.1089/TEN.TEB.2011.0077