Intraseason Waning of Influenza Vaccine Effectiveness.
作者： G Thomas Ray , Ned Lewis , Nicola P Klein , Matthew F Daley , Shirley V Wang
DOI: 10.1093/CID/CIY770
关键词:
摘要: BACKGROUND In the United States, it is recommended that healthcare providers offer influenza vaccination by October, if possible. However, vaccine's effectiveness soon begins to wane, optimal time for may be somewhat later. We examined whether of vaccine wanes during season with increasing since vaccination. METHODS identified persons who were vaccinated inactivated from 1 September 2010 31 March 2017 and subsequently tested respiratory syncytial virus (RSV) a polymerase chain reaction test. Test-confirmed was primary outcome days-since-vaccination predictor interest in conditional logistic regression. Models adjusted age conditioned on calendar day geographic area. RSV used as negative-control outcome. RESULTS Compared 14 41 days prior being tested, 42 69 had 1.32 (95% confidence interval [CI], 1.11 1.55) times odds testing positive any influenza. The ratio (OR) increased linearly approximately 16% each additional 28 OR 2.06 CI, 1.69 2.51) 154 or more tested. No evidence waning found RSV. CONCLUSIONS Our results suggest course single season. These lead reconsideration timing seasonal
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