MNNG-induced Cell Death Is Controlled by Interactions between PARP-1, Poly(ADP-ribose) Glycohydrolase, and XRCC1
作者： Claudia Keil , Tina Gröbe , Shiao Li Oei
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摘要: PARP-1 (poly(ADP-ribose) polymerases) modifies proteins with poly(ADP-ribose), which is an important signal for genomic stability. ADP-ribose polymers also mediate cell death and are degraded by poly(ADP-ribose) glycohydrolase (PARG). Here we show that the catalytic domain of PARG interacts automodification PARP-1. Furthermore, can directly down-regulate activity. XRCC1, a DNA repair factor recruited damage-activated We investigated role XRCC1 in after treatment supralethal doses alkylating agent MNNG. Only XRCC1-proficient cells MNNG induced considerable accumulation poly(ADP-ribose). Similarly, extracts XRCC1-deficient produced large if supplemented XRCC1. Consequently, triggered translocation apoptosis inducing from mitochondria to nucleus followed caspase-independent death. In cells, same caused non-apoptotic without Thus, seems be involved regulating poly(ADP-ribose)-mediated apoptotic
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