Copy number variation on chromosome 10q26.3 for obesity identified by a genome-wide study.
作者： Tie-Lin Yang , Yan Guo , Hui Shen , Jian Li , Joseph T Glessner
DOI: 10.1210/JC.2012-2751
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摘要: Background: Obesity is a highly heritable disease defined by high body mass index (BMI). However, large proportion of the heritability obesity remains unexplained. Copy number variations (CNVs) might contribute to missing obesity. Methods: We conducted genome-wide CNV analyses on phenotypes, including BMI and fat in discovery sample 2215 unrelated white subjects. After quality control, 314 CNVs were used for association tests. For significant identified, follow-up replication performed three independent samples, an 1000 subjects (OM sample), family-based 8385 (FHS African-American 1479 cases 1575 lean controls (AA sample). Results: Genome-wide detected that located at 10q26.3, which, even after multiple testing corrections, showed strong with both (P = 2.30 × 10−4, β 2.164) 6....
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