Chronic constipation and treatment options (Review).

摘要: Chronic constipation (CC) is a highly prevalent heterogeneous disorder. Although CC not known to be associated with the development of serious disease or excess mortality, it considerably reduces patients quality life. In addition, represents an economic burden and society. The majority successfully manage disorder by dietary management use laxatives. Patients functional (slow‑transit non‑slow transit constipation) do respond laxatives are small fraction total population complaining constipation. Regardless low number these patients, intractability their symptoms causes psychological social stress greatly impairs Furthermore, consume disproportionate quantity medical resources. It appears that have disturbance in serotonin transmission system, which results cascade alterations gut neuroendocrine hormones/transmitters. effect prucalopride, receptor agonist, this category only pharmacological prokinetic action, but also correction pre‑existing disturbance. Linaclotide, member guanylin peptide family, binds ligand‑binding region guanylate cyclase‑C on luminal surface gastrointestinal epithelia resulting increased fluid secretion. This drug has been found effective for treatment CC. biofeedback sacral nerve stimulation caused pelvic floor disorders.