Steric Effects in Forward and Reverse Menschutkin Reactions of Some Pyridines, Quinolines and Thiazoles

摘要: The effects of ortho alkyl substituents on the rates methylation pyridine and demethylation N-methylpyridinium iodides are compared (some quinolines included as 'substituted pyridines'). For monosubstituted compounds, substituent steric twice important in (forward) reaction reaction. In contrast, ratio is 3 : 1 for disubstituted because additive reverse but greater than forward Some thiazole results also reported and, here, small while no acceleration evident.