Deep brain stimulation of the nucleus accumbens shell induces anti-obesity effects in obese rats with alteration of dopamine neurotransmission
作者： Chao Zhang , Nai-Li Wei , Yao Wang , Xiu Wang , Jian-Guo Zhang
DOI: 10.1016/J.NEULET.2015.01.019
关键词:
摘要: Abstract The aim of this study was to assess the anti-obesity effects nucleus accumbens shell (NAc-sh) deep brain stimulation (DBS) in diet-induced obese (DIO) and chow-fed (chow) rats. influence DBS on dopamine (DA) signaling NAc-sh also evaluated. DIO chow rats were subjected for 14 consecutive days. Food intake weight gain measured daily. gene expression D1 D2 receptors evaluated by qPCR. In addition, extracellular levels DA its metabolite, dihydroxyphenylacetic acid (DOPAC), determined microdialysis. We observed that chronic induced significant reductions total energy (596.0 ± 65.0 kcal vs. 1161.6 ± 22.2 kcal, p 9.64 ± 0.38%, 0.64 ± 0.04, 0.62 ± 0.05 pmol/mL,
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