Tear size and location impacts false lumen pressure in an ex vivo model of chronic type B aortic dissection

摘要: Background Follow-up mortality is high in patients with type B aortic dissection (TB-AD) approaching one four at 3 years. A predictor of increased partial thrombosis the false lumen which may occlude distal tears. The hemodynamic consequences differing tear size, location, and patency within largely unknown. We examined impact intimal number, location on pressure. Methods In an ex-vivo model chronic connected to a pulsatile pump, simultaneous pressures were measured true lumen. Experiments performed different models sizes 6.4 mm 3.2 following configurations; A: proximal simulating most common state TB-AD; B: only occlusion tear; C: sealed proximally via stent graft persistent communication. To compare diastolic pressure between models, index (FPI%) was calculated for all simulations as FPI% = (false pressure/true pressure) × 100. Results A, systolic slightly lower compared while (DP) higher (DP 66.45 ± 0.16 Hg vs 66.20 0.12 Hg, P 2 0.69) per 10 beat minute increase heart rate ( Conclusions this dissection, highest setting smaller size lack tear. These determinants inflow outflow expansion rupture during follow-up period.