作者: Jon Deane Waldman , Amnon Rosenthal , Arnold L. Smith , Susan Shurin , Alexander S. Nadas
DOI: 10.1016/S0022-3476(77)80365-X
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摘要: Fifty-nine children with congenital asplenia were reviewed for episodes of severe infection. Seven childrenhad isolated and 52 had associated complex heart disease (asplenia syndrome). A control group eusplenic comparable cardiac lesions was assembled used comparative statistical analysis. There 16 instances documented sepsis among 59 (27%). In those less than six months age, the invading organism usually gram-negative ( Escherichia coli or Klebsiella ). age older, infecting a pneumococcus H. influenzae . When syndrome compared to population, former significantly greater incidence sepsis. Children who survived first month life at risk dying from their disease. It is recommended that prophylactic antibiotics be administered absence spleen, commencing three continued indefinitely.