The Placental Variant of Human Growth Hormone Reduces Maternal Insulin Sensitivity in a Dose-Dependent Manner in C57BL/6J Mice.

摘要: The human placental GH variant (GH-V) is secreted continuously from the syncytiotrophoblast layer of placenta during pregnancy and thought to play a key role in maternal adaptation pregnancy. Maternal GH-V concentrations are closely related fetal growth humans. has also been proposed as potential candidate mediate insulin resistance observed later To determine effect administration on metabolic outcomes pregnancy, we examined dose-response relationship for mouse model normal Pregnant C57BL/6J mice were randomized receive vehicle or (0.25, 1, 2, 5 mg/kg · d) by osmotic pump gestational days 12.5 18.5. Fetal linear was slightly reduced dose compared with 0.25 groups, respectively, whereas weight not affected. treatment did affect body weights food intake. However, d significantly increased fasting plasma impaired sensitivity at day 18.5 assessed homeostasis assessment. At d, there an increase hepatic receptor/binding protein (Ghr/Ghbp) IGF binding 3 (Igfbp3) mRNA levels, but alter IGF-1 Igf-1 expression. Our findings suggest that higher doses, can cause hyperinsulinemia likely mediator associated late