GSK3β Interactions with Amyloid Genes: An Autopsy Verification and Extension.

摘要: Glyocogen synthase kinase 3 (GSK3) plays an important role in the pathophysiology of Alzheimer’s disease (AD) through phosphorylation tau. Recent work has suggested that GSK3β also a amyloid pathway AD genetic interactions with APP and APBB2 on vivo measures amyloid. This project extends previously identified genotype to autopsy measure amyloid, while testing same leveraging gene expression data quantified prefrontal cortex. 797 participants (251 cognitively normal, 196 mild cognitive impairment, 350 disease) were drawn from Religious Orders Study Rush Memory Aging Project. A mean score load was calculated across eight brain regions, levels frozen sections dorsolateral cortex using RNA amplification, signals generated Beadstudio. Three SNPs genotyped Illumina 1M genotyping chip. Covariates included age, sex, education, diagnosis. We able evaluate 2 interactions, which interaction between (rs334543) (rs2585590) found this sample (p = 0.04). observed comparable when comparing highest tertile lowest tertile, t(1) −2.03, p 0.043. These results provide additional evidence further suggest is involved both primary neuropathologies disease.