Pramipexole Upregulates Dopamine Receptor D2 and D3 Expression in Rat Striatum
作者： Naohito Tokunaga , Mohammed Emamussalehin Choudhury , Noriko Nishikawa , Masahiro Nagai , Tomoaki Tujii
DOI: 10.1254/JPHS.12096SC
关键词:
摘要: Randomized clinical trials have shown that pramipexole has an antidepressant effect in patients with Parkinson's disease. We investigated the comparative efficacy of toward dopamine receptor D(2) and D(3) expression rat brain. Groups rats were treated subacutely (1 mg/kg), imipramine (10 or bromocriptine (5 appropriate controls. Using real-time RT-PCR immunoblotting, was up-regulated striatum following treatment, while had no significant effects. These findings support exerts additional therapeutic benefits such as decreasing depression by increasing striatum.
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