Protein Modifications and Interactions in Alzheimer’s Disease

摘要: Alzheimer’s disease, an age-related neurodegenerative is characterized by several coincidental features including neuronal loss, neurofibrillary tangles and senile plaques. While the precise mechanism(s) underlying disease are incompletely understood, it apparent that age essential since rarely strikes prior to 55. Many other conditions such as emphysema, arthritis, atherosclerosis also show penetrance occur after normal reproductive life span. This latter aspect especially important there very little evolutionary pressure maintain physiological relationships between biomolecules preclude development of these diseases. lack selection allows altered or novel macromolecular relationships. Our hypothesis protein interactions modifications could destabilize homeostatic and/or be themselves damaging cellular system promoting pathogenesis chronic degenerative