Cross-Subject Image Analysis in Diffusion Brain MRI

摘要: markdownabstractAs our life expectancy continues to rise, the prevalence of diseases associated with aging increases correspondingly. For Alzheimer’s disease, this implies that number persons affected, directly or indirectly, will rise dramatically. Early diagnosis, intervention, and ultimately prevention disease are therefore ever more urgent research aims. Advanced neuroimaging techniques such as diffusion MRI, which provides non-invasive insight into brain changes at microstructural level, promising for identification relate early stages disease. Disentangling these pathological from those in ‘normal’ however requires broad spectrum commonly accompany advancing age. Investigating a population-based context poses novel challenges by demanding new advanced methods analyzing large subjects effectively.