Biodegradable nanoparticles containing benzopsoralens : an attractive strategy for modifying vascular function in pathological skin disorders

摘要: Psoralens are often used to treat skin disorders such as psoriasis, vitiligo, and others. The toxicity fast degradation of these drugs can be diminished by encapsulation in drug-delivery systems (DDS). Nanoparticles (NPs) containing the benzopsoralen (BP) (3-ethoxy carbonyl-2H-benzofuro[3,2-e]-1-benzopiran-2-one) were prepared solvent-evaporation technique, parameters particle size, zeta potential, drug-encapsulation efficiency, external morphology evaluated. analysis revealed that NPs spherical with smooth surface diameter 815 ± 80 nm, they present low tendency toward aggregation, efficiency was 74%. intracellular distribution well their uptake tissues monitored using laser confocal microscopy transmission electron (TEM). use a BP association ultraviolet light (360 nm) TEM morphological characteristics cell damage cytosolic vesiculation, mitochondria condensation, swelling both granular endoplasmic reticulum nuclear membrane. primary target DDS vascular system endothelial cells an attractive strategy for modifying function various pathological states disorders, cancer, inflammation. results presented this work indicate poly(lactic-co-glycolic acid) NP should promising sustained release systemic local delivery associated irradiation (PUVA therapy). © 2011 Wiley Periodicals, Inc. J Appl Polym Sci,