Use of cardiac glycosides and risk of glioma.

摘要: Cardiac glycosides induce apoptotic effects on glioma cells, but whether cardiac protect against risk for is unknown. We therefore explored the relation between glycoside use and using a large validated database. performed case-control analysis Clinical Practice Research Datalink involving 2005 cases diagnosed 1995 2012 that were individually matched to 20,050 controls age, gender, general practice, number of years active history in Conditional logistic regression was used evaluate association adjusting body mass index smoking. also examined common heart failure arrhythmia medications differentiate specific effect generic treatment congestive or arrhythmia. inversely related incidence. After adjustment failure, arrhythmia, diabetes, treat those conditions, OR 0.47 (95% CI 0.27-0.81, Bonferroni-corrected p value = 0.024) versus non-use glycosides, based 17 exposed cases. In contrast, no associations noted other arrhythmias. The people with 0.65 0.40-1.04), it 1.01 0.78-1.31). These data indicate independently associated reduced risk.