MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer
作者： Yanjun Cai , Jian Ruan , Xueqing Yao , Liang Zhao , Baocheng Wang
DOI: 10.3892/OR.2017.5548
关键词:
摘要: MicroRNAs (miRNAs) that negatively regulate gene expression play a key role in the development and progression of cancer. Aberrant hsa-miR-187 (miR-187) has been reported various malignancies. However, function miR-187 tumor remains controversial its non-small cell lung cancer (NSCLC) is poorly understood. In present study, NSCLC was investigated. Our results revealed frequently upregulated tissues cells. Furthermore, ectopic introduction promoted migration, whereas inhibitor had contrary effect Of significance, induced epithelial-mesenchymal transition (EMT), which plays pivotal initiation metastasis activated mitogen-activated protein kinase (MAPK) phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) pathways. Polymerase I transcript release factor (PTRF) identified as direct target promotion migration Restored PTRF neutralized promoting on EMT Collectively, our data highlight NSCLC, indicating this potential candidate molecular therapy.
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