8.03 Reduction of C N to CHNH by Hydride Delivery from C

摘要: The reduction of imines by hydride delivery from C provides alternatives to traditional methods in which H 2 and metal hydrides are used as reductants for the synthesis amines. Since 1990s highly enantioselective reductions have been achieved founded on new catalytic strategies. Starting with a brief description difficulties arising imine substrates different sources strategies manage this transformation, chapter examines transfer hydrogenation using formic acid, 2-propanol, Hantzsch esters, other N -heterocycles, well indirect reductive silanes alternative organic reductants. Novel organocatalytic approaches played an important role highlighted text. An overview scope, conditions, effectiveness, selectivity reaction is provided, evaluating advantages weaknesses Finally, recent progress amines through amination discussed.