The ketogenic diet is not effective in preclinical models of IDH1 wild-type and IDH1 mutant glioma

摘要: Infiltrative gliomas are the most common neoplasms arising in brain, and remain largely incurable despite decades of research. A subset these contains mutations isocitrate dehydrogenase 1 (IDH1 mut ). This mutation disrupts cellular biochemistry, IDH1 generally less aggressive than wild-type wt ) gliomas. Some preclinical studies clinical trials have suggested that a ketogenic diet (KD), characterized by low-carbohydrate high-fat content, may be beneficial slowing glioma progression. However, not all shown promising results, to date, no study has addressed whether might more sensitive KD. The aim current was compare effects KD models versus In vitro , simulating treatment with ketone body β-hydroxybutyrate had effect on proliferation patient-derived or cells. Likewise, vivo growth Furthermore, mice engrafted Sleeping-Beauty transposase-engineered showed difference survival while These data suggest responsive KD, further exploring this patients warranted.