A Comparison of Polyethylene Glycol Laxative and Placebo for Relief of Constipation From Constipating Medications

摘要: OBJECTIVES Medications often cause constipation and little data are available concerning treatment interventions. This study was designed to evaluate the safety efficacy of polyethylene glycol (PEG) 3350 laxative (MiraLax) for relief from medicines associated with symptoms constipation. METHODS Study subjects were enrolled who met defined criteria chronic also taking medications that a reported side effect incidence more than 3% Subjects randomized into double-blind, parallel, multicenter where they received 17 g per day PEG or placebo 28 days. The primary variable, "Treatment Success," as ROME II over last 7 days period. Various secondary measures assessed. Daily bowel movement experience, patient perception efficacy, information recorded in diary. Laboratory testing performed at baseline end hematology blood chemistry, including BUN, calcium, electrolytes, TSH. RESULTS One hundred patients 4 centers. Successful according variable seen 78.3% 39.1% (P < 0.001). Similar results observed subgroup elderly subjects. Secondary number movements, complete satisfactory straining stool consistency showed statistically significant favor compared = 0.01) after first week treatment. There no differences inpatient scores gas, cramping, bloating between placebo. No laboratory findings adverse events, gastrointestinal category, observed. Diarrhea flatulence occurred frequently treatment, although not individually different when these analyzed due gender, race, age. CONCLUSIONS is safe effective use treating constipating medications.