ErbB2 Trafficking and Signaling in Human Vestibular Schwannomas

作者: Marlan R. Hansen , J. J. Clark , Wie Y. Yue , Prabhat C. Goswami , Bruce J. Gantz

DOI: 10.21236/ADA501648

关键词:

摘要: Abstract : We find that the ErbB2 receptor tyrosine kinase is active in vestibular schwannoma (VS) cells and drives proliferation. Our overall hypothesis defects merlin lead to constitutive activation at cell membrane inhibition of will reduce survival VS potentiate effects radiation on VSs. In this report we show cells, which lack functional merlin, constitutively express activated lipid rafts contributing their proliferative potential; related status cells. Furthermore, protein A inactivates by phosphorylation Schwann vitro vivo following denervation, correlated with movement into lipids re-entry cycle. are relatively radioresistance, due least part, persistent JNK activity promotes limits oxidative stress. Finally, reduces radiosensitivity whereas enhances radiosensitivity, likely regulating

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