Changes in Follicular CD4+ T Helper Cells as a Marker for Evaluating Disease Progression in the Competition between HIV and Host Immunity.

作者: Xiaolei Wang , Widade Ziani , Huanbin Xu

DOI: 10.3389/FIMMU.2016.00474

关键词:

摘要: Follicular CD4+ T helper (TFH) cells interact with B in follicular germinal centers and play a prominent role promoting effective humoral immune responses to pathogens, providing help for cell development, antibody affinity maturation. Recent studies indicate TFH are expanded HIV/SIV chronic infection, or depleted terminal stages of disease, yet relatively maintained elite controllers when compared uninfected controls. A better understanding the mechanisms behind these immunologic abnormalities may lead more vaccination therapeutic strategies. Here we review recent findings discuss correlation changes function host immunity. Dysregulation depletion likely plays major inability HIV infected patients mount responses.

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