Inhibition by docosahexaenoic acid of receptor-mediated Ca2+ influx in rat vascular smooth muscle cells stimulated with 5-hydroxytryptamine
作者： Masahiko Hirafuji , Takashi Ebihara , Fumito Kawahara , Noaya Hamaue , Toru Endo
DOI: 10.1016/S0014-2999(01)01274-2
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摘要: The effect of docosahexaenoic acid treatment on intracellular Ca(2+) dynamics in rat vascular smooth muscle cells stimulated with 5-hydroxytryptamine (5-HT) has been investigated order to elucidate one the mechanisms for its beneficial cardiovascular disorders. 30 microM 2 days inhibited an increase concentration induced by 5-HT (10 microM) and a depolarizing KCl (80 mM). Docosahexaenoic significantly divalent cation influx KCl, as measured Mn(2+) quenching method, whereas had no 5-HT-induced release from internal stores. also receptor-mediated through Ni(2+)-insensitive channels that were distinct store-operated channels. These results suggest specific inhibition may contribute properties
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