Is PfCRT a channel or a carrier? Two competing models explaining chloroquine resistance in Plasmodium falciparum.
作者： Cecilia P. Sanchez , Wilfred D. Stein , Michael Lanzer
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摘要: Chloroquine (CQ), an antimalarial drug with a long history, now frequently fails in the field owing to rapid spread of resistant Plasmodium falciparum strains. CQ resistance is linked K76T mutation PfCRT, membrane-located food vacuolar protein and member drug-metabolite transporter superfamily, but there as yet no agreed mechanism how mutated PfCRT brings about resistance. Current models suggest that acts either channel or CQ, enabling leave digestive vacuole parasite, which accumulates. Here, we review pros cons carrier light recent developments field.
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A. Yayon, Z.I. Cabantchik, H. Ginsburg, Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine. The EMBO Journal. ,vol. 3, pp. 2695- 2700 ,(1984) , 10.1002/J.1460-2075.1984.TB02195.X
Wilfred D. Stein, W. R. Lieb, Transport and Diffusion Across Cell Membranes ,(1986)
Timothy G. Geary, Alan D. Divo, James B. Jensen, Marina Zangwill, Hagai Ginsburg, Kinetic modelling of the response of Plasmodium falciparum to chloroquine and its experimental testing in vitro Biochemical Pharmacology. ,vol. 40, pp. 685- 691 ,(1990) , 10.1016/0006-2952(90)90302-2
Michael T. Ferdig, Roland A. Cooper, Jianbing Mu, Bingbing Deng, Deirdre A. Joy, Xin-zhuan Su, Thomas E. Wellems, Dissecting the loci of low‐level quinine resistance in malaria parasites Molecular Microbiology. ,vol. 52, pp. 985- 997 ,(2004) , 10.1111/J.1365-2958.2004.04035.X
Patrick G. Bray, Mathirut Mungthin, Robert G. Ridley, Stephen A. Ward, Access to Hematin: The Basis of Chloroquine Resistance Molecular Pharmacology. ,vol. 54, pp. 170- 179 ,(1998) , 10.1124/MOL.54.1.170
D. J. Sullivan, I. Y. Gluzman, D. G. Russell, D. E. Goldberg, On the molecular mechanism of chloroquine's antimalarial action. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 11865- 11870 ,(1996) , 10.1073/PNAS.93.21.11865
Can V Tran, MH, Jr Saier, None, The principal chloroquine resistance protein of Plasmodium falciparum is a member of the drug/metabolite transporter superfamily. Microbiology. ,vol. 150, pp. 1- 3 ,(2004) , 10.1099/MIC.0.26818-0
Angel C. de Dios, Robert Tycko, Lyann M. B. Ursos, Paul D. Roepe, NMR Studies of Chloroquine-Ferriprotoporphyrin IX Complex Journal of Physical Chemistry A. ,vol. 107, pp. 5821- 5825 ,(2003) , 10.1021/JP0342982
Sergey M. Dzekunov, Lyann May B. Ursos, Paul D. Roepe, Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine Molecular and Biochemical Parasitology. ,vol. 110, pp. 107- 124 ,(2000) , 10.1016/S0166-6851(00)00261-9
Cecilia P. Sanchez, Wilfred Stein, Michael Lanzer, Trans stimulation provides evidence for a drug efflux carrier as the mechanism of chloroquine resistance in Plasmodium falciparum. Biochemistry. ,vol. 42, pp. 9383- 9394 ,(2003) , 10.1021/BI034269H