Antithrombotic medication and endovascular interventions associated with short-term exposure to particulate air pollution: A nationwide case-crossover study.

摘要: Abstract Short-term exposure to air pollution has pro-thrombotic effects and triggers thrombo-embolic events such as myocardial infarction or stroke in adults. This study evaluates the association between short-term variation treatments for acute among whole Belgian population. In a bidirectional time-stratified case-crossover design, we included 227,861 treated with endovascular intervention 74,942 antithrombotic enzymes that were reimbursed by Social Security January 1st, 2009 December 31st, 2013. We compared concentrations of particulate matter (PM) (PM10 PM2.5), estimated at municipality level on day event (lag 0) two days earlier 1 lag 2) those control from same month, matched temperature accounting week (weekend vs days). applied conditional logistic regression models obtain odds ratios (OR) their 95% CI an increase 10 μg/m3 (PM10) 5 μg/m3 (PM2.5) pollutant over three 0, 2). observed significant associations PM10 PM2.5 treatment lags. The strongest (lag0). Increases lag0 increased 2.7% (95%CI:2.3%–3.2%) 1.3% (95%CI:1%–1.5%), respectively, they 1.9% (95%CI:1.1–2.7%) 1.2% (95%CI:0.7%–1.6%), respectively. generally stronger during autumn months children. Our nationwide confirms outdoor pollutants use medication interventions treat events.