Isosorbide dinitrate inhibits mechanical stress-induced cardiac hypertrophy and autophagy through downregulation of angiotensin II type 1 receptor.
作者： Li Lin , Jianfeng Xu , Yong Ye , Junbo Ge , Yunzeng Zou
DOI: 10.1097/FJC.0000000000000122
关键词:
摘要: Mechanical stress can induce cardiac hypertrophy and autophagy. Recently, it has been reported that nitric oxide donors inhibited autophagy in human chondrocytes. Therefore, the effect of isosorbide dinitrate (ISDN) on induced by mechanical was investigated this study. A 48-hour stretch a 4-week transverse aortic constriction were performed to cardiomyocyte vitro vivo, respectively, before assessment myocardial using LC3b-II. ISDN found significantly reduce stretch-induced LC3b-II upregulation. Furthermore, shown upregulate angiotensin II (AngII) type 1 (AT1) receptor expression both cultured cardiomyocytes mouse hearts, whereas demonstrated suppress upregulation AT1 receptor. It concluded could inhibit stress-induced through downregulation expression.
wkhealth.com参考文章(38)
Walter J. Paulus, The role of nitric oxide in the failing heart. Heart Failure Reviews. ,vol. 6, pp. 105- 118 ,(2001) , 10.1007/978-1-4615-1449-7_5
Mattias Carlström, A. Erik G. Persson, Erik Larsson, Michael Hezel, Peter G. Scheffer, Tom Teerlink, Eddie Weitzberg, Jon O. Lundberg, Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension Cardiovascular Research. ,vol. 89, pp. 574- 585 ,(2011) , 10.1093/CVR/CVQ366
Hongxin Zhu, Paul Tannous, Janet L. Johnstone, Yongli Kong, John M. Shelton, James A. Richardson, Vien Le, Beth Levine, Beverly A. Rothermel, Joseph A. Hill, Cardiac autophagy is a maladaptive response to hemodynamic stress Journal of Clinical Investigation. ,vol. 117, pp. 1782- 1793 ,(2007) , 10.1172/JCI27523
Yunzeng Zou, Hiroshi Akazawa, Yingjie Qin, Masanori Sano, Hiroyuki Takano, Tohru Minamino, Noriko Makita, Koji Iwanaga, Weidong Zhu, Sumiyo Kudoh, Haruhiro Toko, Koichi Tamura, Minoru Kihara, Toshio Nagai, Akiyoshi Fukamizu, Satoshi Umemura, Taroh Iiri, Toshiro Fujita, Issei Komuro, Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II Nature Cell Biology. ,vol. 6, pp. 499- 506 ,(2004) , 10.1038/NCB1137
David W. Brown, Wayne H. Giles, Janet B. Croft, Left ventricular hypertrophy as a predictor of coronary heart disease mortality and the effect of hypertension American Heart Journal. ,vol. 140, pp. 848- 856 ,(2000) , 10.1067/MHJ.2000.111112
Beverly H. Lorell, Blase A. Carabello, Left Ventricular Hypertrophy Pathogenesis, Detection, and Prognosis Circulation. ,vol. 102, pp. 470- 479 ,(2000) , 10.1161/01.CIR.102.4.470
Andreas Schäfer, Daniela Fraccarollo, Piet Tas, Isabel Schmidt, Georg Ertl, Johann Bauersachs, Endothelial dysfunction in congestive heart failure: ACE inhibition vs. angiotensin II antagonism European Journal of Heart Failure. ,vol. 6, pp. 151- 159 ,(2004) , 10.1016/J.EJHEART.2003.10.009
Michael J Koren, Richard B Devereux, Paul N Casale, Daniel D Savage, John H Laragh, Relation of Left Ventricular Mass and Geometry to Morbidity and Mortality in Uncomplicated Essential Hypertension Annals of Internal Medicine. ,vol. 114, pp. 345- 352 ,(1991) , 10.7326/0003-4819-114-5-345
Kenneth M Baker, Mitchell I Chernin, Taylor Schreiber, Sandhya Sanghi, Seema Haiderzaidi, George W Booz, David E Dostal, Rajesh Kumar, Evidence of a novel intracrine mechanism in angiotensin II-induced cardiac hypertrophy. Regulatory Peptides. ,vol. 120, pp. 5- 13 ,(2004) , 10.1016/J.REGPEP.2004.04.004
Ajay M Shah, Douglas L Mann, In search of new therapeutic targets and strategies for heart failure: recent advances in basic science. The Lancet. ,vol. 378, pp. 704- 712 ,(2011) , 10.1016/S0140-6736(11)60894-5