New quinazoline derivatives

摘要: The invention comprises compounds of the formula wherein R1 and R2 each stand for hydrogen or an alkyl radical not more than 6 carbon atoms, X stands 3 Y hydrogen, halogen atoms Z group NHR3, R3 acyl is located at position 7 8 quinazoline ring system. Such are obtained by reduction nitro system, product being subsequently acylated if necessary. can be effected use stannous chloride metallic powders such as iron, tin zinc, in aqueous acid medium. In examples: (1) 4-amino-7-nitro-quinazoline reduced with iron powder dilute hydrochloric to 4:7-diaminoquinazoline; (2) reacted acetic anhydride glacial give 7-acetamido - 4 amino quinazoline. other examples there prepared (3) 7-amino-4-methylaminoquinazoline; (4) dimethylaminoquinazoline; (5) ethylaminoquinazoline; (6) 7-amino-4-isopropylaminoquinazolines; (7) 7-amino-4-n-butylaminoquinazoline; (8) 7-acetamido-4-n-butylaminoquinazoline; (9) 4:8-diaminoquinazoline; (10) 6-chloro-4:8-diamino-quinazoline. Also mentioned 4:7-diamino-2- 6-methyl quinazolines, butyramidoquinazoline. methylamino nitroquinazoline reacting 4-chloro-7-nitroquinazoline methylamine. Similarly 7-nitroquinolines 4-substituents specified above examples. Amino heating 4-chloro-8-nitroquinazoline phenol ammonium carbonate resulting sodium acetate 140-150 DEG C. chloro 3-nitro-5-chloro-anthranilic formamide 6-chloro-4-hydroxy-8-nitro-quinazoline, which treated phosphorus pentachloride 4:6 dichloro nitroquinazoline. This compound heated gives phenoxyquinazoline, required product.