MHC Control of Growth and Metastatic Properties of Tumor Cells

摘要: The question whether cancer cells possess specific cell surface antigens which do not appear on normal of the human organism has intrigued scholars since early days research. obvious aim was to identify cancer-specific in order use them as vaccines for immunotherapy cancer. Yet, all attempts demonstrate tumor failed, detected were found exist also cells. first demonstration that may came from experiments tumors induced mice by a chemical carcinogen, polycyclic hydrocarbon methylcholanthrene, tested antigenic specificity. When primary transplanted syngeneic animals, they grew; however, if following their initial growth surgically removed and animals with second graft same tumor, this transplant rejected (Foley 1953; Prehn Main 1957). Thus, elicited transplantation immunity strong enough prevent tumor. Since grafts tissues tumor-bearing did elicit an immune response against subsequent graft, rejection secondary attributed tumor-specific (Prehn