Processing mitochondrial (t)RNAs: new enzyme, old job.

摘要: While the principal mode of synthesis different human mitochondrial RNA species was recognized almost three decades ago, constituents one key players postulated processing machinery were identified only recently. Human RNase P, endonuclease responsible for tRNA 5’ end maturation, turned out to be unlike any its previously characterized cousins. It is not devoid moiety thought diagnostic this type enzymes so far, but it instead built like a patchwork multifunctional proteins coming together moonlight in cleavage.1