Does stimulant therapy of attention-deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literature.

摘要: Objective.Concerns exist that stimulant therapy of youths with attention-deficit/hyperactivity disorder (ADHD) may result in an increased risk for subsequent substance use disorders (SUD). We investigated all long-term studies which pharmacologically treated and untreated ADHD were examined later SUD outcomes. Methods.A search available prospective retrospective children, adolescents, adults had information relating childhood exposure to outcome adolescence or adulthood was conducted through PubMed supplemented data from scientific presentations. Meta-analysis used evaluate the relationship between general while addressing specifically differential effects on alcohol drug potential covariates. Results.Six studies—2 follow-up 4 young adulthood—were included comprised 674 medicated subjects 360 unmedicated who followed at least years. The pooled estimate odds ratio indicated a 1.9-fold reduction stimulants compared did not receive pharmacotherapy (z = 2.1; 95% confidence interval [OR]: 1.1–3.6). found similar reductions 1.1). Studies reported into showed greater protective effect development (OR: 5.8) than 1.4). Additional analyses results could be accounted by any single study publication bias. Conclusion.Our suggest is associated disorders.