Diverse facets of cortical interneuron migration regulation - Implications of neuronal activity and epigenetics.

摘要: The proper function of the cerebral cortex relies on delicate balance excitation and inhibition determined by accurate number subtype composition diverse group inhibitory gamma-aminobutyric (GABA)-expressing interneurons. Developmental defects can lead to impaired cortical seem implicated in neuropsychiatric disorders like schizophrenia. multifaceted development interneurons, which long-range migration from basal telencephalon targets represents a critical step, is orchestrated various intrinsic extrinsic factors. Besides motogenic factors, neuronal activity neurotransmitter calcium signaling turned out as crucial driver interneuron motility migration, whereas directionality specific guidance receptors. Thereby, responses towards different neurotransmitters cues appear highly stage cell type- specific, relying complex transcriptional network that instruct expression particular receptor combinations. contribution epigenetic mechanisms gene control direct maturation are now beginning be approached. This key decipher subtype-specific developmental programs helps understand how environmental signals shape maturation. review provides an overview about achievements were made uncovering regulatory networks orchestrating distinct subtypes with focus role control.