Polypropylene in the intra-abdominal position: influence of pore size and surface area.

摘要: Background. Polypropylene is a material widely used in surgery. Because of its association with formation enterocutaneous fistulae and adhesions, direct contact between mesh intestine avoided. The following study was designed to investigate the adhesive potential different polypropylene meshes when placed intestine. Material methods. In an established experimental model, total 45 chinchilla rabbits underwent laparoscopic placement pore size (Group I: monofilament PP 0.6 mm, Group II: 2.5 III: multifilament 4.0 mm) Intra-Peritoneal-Onlay-Mesh Technique (IPOM). degree adhesion measured after 7, 21, 90 days, evaluated by score, quantified computer-assisted planimetry, followed histological morphometric investigation perifilamental granuloma formation. Results. heavyweight, small porous (PP 0.6) showed significantly stronger at all intervals compared lightweight >2.5 mm. Between two variations, there no significant difference. Granuloma lowest large-pore-size 2.5). Conclusion. IPOM rabbit model suitable for biomaterials intra-abdominal position. Our results show that influenced size. However, extent foreign-body reaction seems also be filament structure, respectively, surface area, favouring material.