Growth and development in children with sickle-cell trait. A prospective study of matched pairs.

摘要: To ascertain if sickle-cell trait (Hb AS) impairs physical growth and cognitive development, we prospectively investigated 50 matched pairs of black children. For each child with Hb AS, an AA was at birth for sex, date, weight, gestational age, five-minute Apgar score socioeconomic status. Between the ages three five years, members pair were evaluated, one month another, by persons "blind" to hemoglobin genotype. Twelve outcome measurements obtained evaluation: height, head circumference, skin-fold thickness, cross-sectional area arm muscle, bone scores McCarthy Scales Children's Abilities, Peabody Picture Vocabulary Test. There no statistically significant differences in these favoring group. The results show that children this age group have deficits standard development emphasize importance rigorous methods when clinical groups are assembled compared.