Bioinformatics and genomic analysis of transposable elements in eukaryotic genomes.

摘要: A major portion of most eukaryotic genomes are transposable elements (TEs). During evolution, TEs have introduced profound changes to genome size, structure, and function. As integral parts genomes, the dynamic presence will continue be a force in reshaping genomes. Early computational analyses sequences focused on filtering out “junk” facilitate gene annotation. When high abundance diversity were recognized, these early efforts transformed into systematic genome-wide categorization classification TEs. The availability genomic sequence data reversed classical genetic approaches discovering new TE families superfamilies. Curated databases their accurate annotation turn facilitated studies number frontiers including: (1) TE-mediated size (2) influence functions, (3) regulation by host, (4) evolution population dynamics, (5) scale activity. Bioinformatics become an part large-scale extract information with pure silico or assist wet lab experimental studies. current revolution sequencing technology facilitates further progress existing research emergence initiatives. rapid generation large-sequence datasets at record low costs routine basis is challenging computing industry storage capacity manipulation speed bioinformatics community for improvement algorithms implementations.