High progesterone levels are associated with family history of premature coronary artery disease in young healthy adult men

摘要: Background & aims The offspring of patients with premature coronary artery disease (P-CAD) are at higher risk for cardiovascular disease, compared subjects without a family history (FH) P-CAD. increased in FH early-onset CAD results from unfavorable genetic variants as well social, behavioral and environmental factors, which more prevalent this group. Previous studies have shown that specific sex hormone levels may be associated the disease. aim study was to compare wide range biochemical marker including i.e. luteinizing (LH), follicle-stimulating (FSH), progesterone, estradiol, testosterone sex-hormone binding globulin (SHBG) between young healthy male adults Methods group consisted Polish enrolled MAGNETIC case-control study, who were recruited July 2015 October 2017. inclusion criteria follows: sex, age ≥18 ≤35 years old, P-CAD (cases) or no first-degree relatives (controls). comparison continuous categorical variables performed using Student's t-test U-Mann-Whitney test, Fisher's exact respectively. correlations FSH, LH, testosterone, SHBG other laboratory parameters assessed Spearman rank correlation test. Both univariable multivariable logistic regression analyses assess association analyzed Results A total 411 (223 cases 188 controls) included study. There prevalence major factors (smoking, LDL cholesterol levels, body mass index lower HDL level). Moreover, had level, LH progesterone crude comparison, individuals After adjustment confounding variables, determined independently Conclusion Progesterone significantly P-CAD, independent traditional CAD.