Mathematical modeling of intraperitoneal drug delivery: simulation of drug distribution in a single tumor nodule

摘要: The intraperitoneal (IP) administration of chemotherapy is an alternative treatment for peritoneal carcinomatosis, allowing higher intratumor concentrations the cytotoxic agent compared to intravenous administration. Nevertheless, drug penetration depths are still limited a few millimeters. It thus necessary better understand limiting factors behind this poor in order improve IP delivery. By developing three-dimensional computational fluid dynamics (CFD) model tumor nodule, we investigated impact number key parameters on transport and depth during chemotherapy. Overall, smaller tumors showed than larger ones, which could be attributed lower IFP tumors. Furthermore, demonstrated large improvements by subjecting nodules vascular normalization therapy, illustrated importance that used therapy. Explicitly modeling necrotic core had effect simulated penetration. Similarly, remained virtually constant when Darcy permeability tissue changed. Our findings illustrate developed parametrical CFD powerful tool providing more insight