Manganese enhances the antitumor function of CD8+ T cells by inducing type I interferon production.

Delphine Goubau, Safia Deddouche, Caetano Reis e Sousa, Cytosolic Sensing of Viruses Immunity. ,vol. 38, pp. 855- 869 ,(2013) , 10.1016/J.IMMUNI.2013.05.007

Samantha S.W. Ho, Wendy Y.L. Zhang, Nikki Yi Jie Tan, Muznah Khatoo, Manuel A. Suter, Shubhita Tripathi, Florence S.G. Cheung, Weng Khong Lim, Puay Hoon Tan, Joanne Ngeow, Stephan Gasser, The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells. Immunity. ,vol. 44, pp. 1177- 1189 ,(2016) , 10.1016/J.IMMUNI.2016.04.010

Hui Yang, Hanze Wang, Junyao Ren, Qi Chen, Zhijian J. Chen, cGAS is essential for cellular senescence Proceedings of the National Academy of Sciences of the United States of America. ,vol. 114, pp. 201705499- ,(2017) , 10.1073/PNAS.1705499114

Pan Chen, Julia Bornhorst, Michael A Aschner, Manganese metabolism in humans Frontiers in Bioscience. ,vol. 23, pp. 1655- 1679 ,(2018) , 10.2741/4665

Brian J. Francica, Ali Ghasemzadeh, Anthony L. Desbien, Debebe Theodros, Kelsey E. Sivick, Gabrielle L. Reiner, Laura Hix Glickman, Ariel E. Marciscano, Andrew B. Sharabi, Meredith L. Leong, Sarah M. McWhirter, Thomas W. Dubensky, Drew M. Pardoll, Charles G. Drake, TNFα and Radioresistant Stromal Cells Are Essential for Therapeutic Efficacy of Cyclic Dinucleotide STING Agonists in Nonimmunogenic Tumors Cancer immunology research. ,vol. 6, pp. 422- 433 ,(2018) , 10.1158/2326-6066.CIR-17-0263

Chenguang Wang, Yukun Guan, Mengze Lv, Rui Zhang, Zhaoying Guo, Xiaoming Wei, Xiaoxia Du, Jing Yang, Tong Li, Yi Wan, Xiaodong Su, Xiaojun Huang, Zhengfan Jiang, Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses Immunity. ,vol. 48, pp. 675- ,(2018) , 10.1016/J.IMMUNI.2018.03.017

Linda Schadt, Colin Sparano, Nicole Angelika Schweiger, Karina Silina, Virginia Cecconi, Giulia Lucchiari, Hideo Yagita, Emilien Guggisberg, Sascha Saba, Zuzana Nascakova, Winfried Barchet, Maries van den Broek, Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity Cell Reports. ,vol. 29, pp. 1236- ,(2019) , 10.1016/J.CELREP.2019.09.065

Lin Hou, Chunyu Tian, Yingshan Yan, Lewen Zhang, Huijuan Zhang, Zhenzhong Zhang, Manganese-Based Nanoactivator Optimizes Cancer Immunotherapy via Enhancing Innate Immunity. ACS Nano. ,vol. 14, pp. 3927- 3940 ,(2020) , 10.1021/ACSNANO.9B06111