Immunohistochemistry for β‐catenin in the differential diagnosis of spindle cell lesions: analysis of a series and review of the literature
作者： J W Carlson , C D M Fletcher
DOI: 10.1111/J.1365-2559.2007.02794.X
关键词:
摘要: Aims: Nuclear staining for β-catenin by immunohistochemistry is being used increasingly to diagnose desmoid tumours (deep fibromatoses), especially where the differential diagnosis includes other abdominal spindle cell neoplasms. This study aimed define prevalence of positivity in and morphologically similar neoplasms. Method results: expression was evaluated 270 soft tissue tumours. immunopositivity detected 80% cases sporadic fibromatosis (24/30) 67% patients with familial adenomatous polyposis (8/12). also present 14/25 superficial fibromatoses (56%), 3/10 low-grade myofibroblastic sarcomas (30%), 5/23 solitary fibrous (22%), 1/5 infantile fibrosarcomas (20%), 1/18 desmoplastic fibroblastomas (6%) 1/21 gastrointestinal stromal (5%). No nuclear immunoreactivity neurofibromas (0/26), schwannomas (0/25), nodular fasciitis (0/19), leiomyosarcomas (0/16), inflammatory (0/12), fibromas tendon sheath (0/9), lipofibromatoses (0/5), Gardner (0/4), calcifying aponeurotic (0/4) or colli (0/1). Conclusion: supportive, but not definitive, fibromatosis. significant difference observed between fibromatoses. β-Catenin negativity does preclude
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