Advanced Synthetic Strategies for Constructing Quinazolinone Scaffolds

摘要: Quinazolinones are important heterocyclic scaffolds because of their broad spectrum medicinal and pharmacological properties. The development advanced synthetic methods to construct the quinazolinone motif is therefore an aspect chemistry. This review emphasises recent developments in methodologies strategies for core. 1 Introduction 2 Synthesis 2-Substituted 2.1 Oxidative Condensation/Cyclization 2.2 Acid-Catalyzed 2.3 Transition-Metal-Catalyzed C–N Bond Formation 2.4 Cyclocarbonylation 3 3-Substituted 3.1 Using a Coupling Agent 3.2 3.3 3.4 4 2,3-Disubstituted 4.1 Dehydrative/Reductive Cyclization 4.2 4.3 Radical 4.4 4.5 4.6 5 Conclusion