Targeted Delivery of Factor VIII proteins to platelets

作者: Henning Stennicke , Eva H. Norling Olsen , Magali A. Zundel , Carsten Behrens , Henrik Østergaard

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摘要: The invention described herein relates to novel molecules and polypeptides comprising at least one amino acid sequence having significant identity with (homology to) human Factor VIII or biologically active portion(s) thereof, related (such as nucleic acids encoding such polypeptides), compositions pharmaceutical formulations) polypeptides, methods of making using polypeptides.

参考文章(21)
Charles T. Esmon, Mikhail D. Smirnov, Modified protein C ,(1996)
Thomas Dr. Weimer, Stefan Dr. Schulte, Hubert Dr. Metzner, Modified coagulation factors with prolonged in vivo half-life ,(2007)
Roy Harris, Nicola Jane Church, Conjugates comprising two active agents ,(1998)
Paolo Ferruti, Luciana Sartore, Elisabetta Ranucci, Paolo Caliceti, Francesco M. Veronese, Oddone Schiavon, Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces ,(1994)
Francesco Maria Veronese, J. Milton Harris, Oddone Schiavon, Paolo Caliceti, Multiarmed, monofunctional, polymer for coupling to molecules and surfaces ,(1995)
L. THIM, B. VANDAHL, J. KARLSSON, N. K. KLAUSEN, J. PEDERSEN, T. N. KROGH, M. KJALKE, J. M. PETERSEN, L. B. JOHNSEN, G. BOLT, P. L. NØRBY, T. D. STEENSTRUP, Purification and characterization of a new recombinant factor VIII (N8). Haemophilia. ,vol. 16, pp. 349- 359 ,(2010) , 10.1111/J.1365-2516.2009.02135.X
Frank Bordusa, Hans-Dieter Jakubke, Eva Hoess, Rupert Herrmann, Wilhelm Tischer, C-terminal modification of polypeptides ,(2005)
Junho Chung, Christoph Rader, Mikhail Popkov, Young‐Mi Hur, Hyun‐Kyung Kim, Young‐Joon Lee, Carlos F. Barbas, Integrin αIIbβ3-specific synthetic human monoclonal antibodies and HCDR3 peptides that potently inhibit platelet aggregation The FASEB Journal. ,vol. 18, pp. 361- 363 ,(2004) , 10.1096/FJ.03-0586FJE
Michael Neyman, Jamie Gewirtz, Mortimer Poncz, Analysis of the spatial and temporal characteristics of platelet-delivered factor VIII-based clots. Blood. ,vol. 112, pp. 1101- 1108 ,(2008) , 10.1182/BLOOD-2008-04-152959