Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae).
作者： Anita M. Brinker , Jun Ma , Peter E. Lipsky , Ilya Raskin
DOI: 10.1016/J.PHYTOCHEM.2006.11.029
关键词:
摘要: Plants in the genus Tripterygium, such as Tripterygium wilfordii Hook.f., have a long history of use traditional Chinese medicine. In recent years there has been considerable interest extracts and main bioactive constituent, diterpene triepoxide triptolide (1), to treat variety autoimmune inflammation-related conditions. The mode action (1) is inhibition expression proinflammatory genes those for interleukin-2 (IL-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha), cyclooxygenase-2 (COX-2) interferon-gamma (IFN-gamma). efficacy safety certain types were confirmed human clinical trials US abroad. Over 300 compounds identified many these evaluated biological activity. overall activity extract based on interaction between its components. Therefore, cannot be fully mimicked by any individual constituent. This review discusses biochemical composition pharmacological activities extracts, their
elsevier.com
sci-hub.se 参考文章(353)
Kostas Dimas, Costas Demetzos, Marios Marsellos, Roula Sotiriadou, Mixalis Malamas, Dimitrios Kokkinopoulos, Cytotoxic activity of labdane type diterpenes against human leukemic cell lines in vitro. Planta Medica. ,vol. 64, pp. 208- 211 ,(1998) , 10.1055/S-2006-957410
Anthony C. Allison, Ramon Cacabelos, Valter R.M. Lombardi, Xoan A. Álvarez, Carmen Vigo, Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease. Progress in Neuro-psychopharmacology & Biological Psychiatry. ,vol. 25, pp. 1341- 1357 ,(2001) , 10.1016/S0278-5846(01)00192-0
Aruna Kapil, Shalini Sharma, Anti-complement activity of oleanolic acid: an inhibitor of C3-convertase of the classical complement pathway. Journal of Pharmacy and Pharmacology. ,vol. 46, pp. 922- 923 ,(2011) , 10.1111/J.2042-7158.1994.TB05715.X
Kyung-Hee Sohn, Ho-Young Lee, Hae-Young Chung, Han-Suk Young, Seh-Yoon Yi, Kyu-Won Kim, Anti-angiogenic activity of triterpene acids Cancer Letters. ,vol. 94, pp. 213- 218 ,(1995) , 10.1016/0304-3835(95)03856-R
Hideji Itokawa, Osamu Shirota, Hiroshi Ikuta, Hiroshi Morita, Koichi Takeya, Yoichi Iitaka, Triterpenes fromMaytenus ilicifolia Phytochemistry. ,vol. 30, pp. 3713- 3716 ,(1991) , 10.1016/0031-9422(91)80096-J
Jiang Du, Ming-Lei Wang, Ruo-Yun Chen, De-Quan Yu, Two new bislabdane-type diterpenoids and three new diterpenoids from the roots of Cunninghamia lanceolata. Planta Medica. ,vol. 67, pp. 542- 547 ,(2001) , 10.1055/S-2001-16491
James Peter Kutney, Kang Han, Francisco Kuri-Brena, Radka K. Milanova, Malcolm Roberts, Studies with plant cell cultures of the Chinese herbal plant, Tripterygium wilfordii. Synthesis and biotransformation of diterpene analogues. Heterocycles. ,vol. 44, pp. 95- 104 ,(1997) , 10.3987/COM-96-S25
Xuelian Tao, Laurie S. Davis, Peter E. Lipsky, Effect of an extract of the Chinese herbal remedy Tripterygium wilfordii Hook F on human immune responsiveness. Arthritis & Rheumatism. ,vol. 34, pp. 1274- 1281 ,(1991) , 10.1002/ART.1780341011
Todd R. Furbacher, A. A. Leslie Gunatilaka, Catalytic inhibition of topoisomerase IIα by demethylzeylasterone, a 6-oxophenolic triterpenoid from Kokoona zeylanica Journal of Natural Products. ,vol. 64, pp. 1294- 1296 ,(2001) , 10.1021/NP010123C
T. Malini, G. Vanithakumari, Antifertility effects of β-sitosterol in male albino rats Journal of Ethnopharmacology. ,vol. 35, pp. 149- 153 ,(1991) , 10.1016/0378-8741(91)90066-M