Pharmaceutical Hydrates Analysis-Overview of Methods and Recent Advances

作者: Ewa Jurczak , Anna Helena Mazurek , Łukasz Szeleszczuk , Dariusz Maciej Pisklak , Monika Zielińska-Pisklak

DOI: 10.3390/PHARMACEUTICS12100959

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摘要: This review discusses a set of instrumental and computational methods that are used to characterize hydrated forms of APIs (active pharmaceutical ingredients). The focus has been put on highlighting advantages as well as on presenting some limitations of the selected analytical approaches. This has been performed in order to facilitate the choice of an appropriate method depending on the type of the structural feature that is to be analyzed, that is, degree of hydration, crystal structure and dynamics, and (de) hydration kinetics. The …

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