Hematologic Manifestations of Trisomy 21

摘要: The most common human chromosome aneuploidy, trisomy 21 (Down syndrome [DS] and Down mosaic), is associated with a wide spectrum of hematologie abnormalities in the three hematopoietic lines. Included these are peculiar findings neonate, transient leukemia (TL), high mean corpuscular volume throughout life, incidence acute megakaryoblastic (AMKL) infancy, increased immunologie system. Most newborns any above-mentioned may not have other clinical sign or symptom. However, some infants TL present massive hepatosplenomegaly, cutaneous infiltrates, hydrops fetalis (Zipursky et al. 1999) liver fibrosis (Yagihashi 1995; AlKasim 2002). Although, thought to be benign self-limited disorder, it can fatal at initial presentation. Moreover, develop one-third patients who initially recover from (Homans 1993).